Learn about options such as analgesics and, Discover the stages of knee osteoarthritis, which range from a normal knee to a severely damaged one. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Plasma levels of clozapine may be increased, resulting in increased pharmacologic and toxic effects. Examples of these blood pressure drugs include: Using the cancer drug pemetrexed with diclofenac may increase the effects of pemetrexed. Avoid or Use Alternate Drug. triclabendazole and fluoxetine both increase QTc interval. fluoxetine, ketorolac intranasal. tipranavir will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Diclofenac may interact with other medications, Important considerations for using diclofenac, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f64b68a5-d6d2-4e92-87e7-90af04c1f9db, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89a7bfbd-051f-4d87-a642-96b0df81b8e2, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=60045fc6-f0d9-4f67-ba91-c3b317596437, Stages of Osteoarthritis (OA) of the Knee, Everything You Need to Know About Sexually Transmitted Infections (STIs), Every Sunscreen Question You Have, Answered. Minor/Significance Unknown. Minor/Significance Unknown. This drug comes with risks if you dont use it as prescribed. Minor/Significance Unknown. Use lowest dose possible and monitor for respiratory depression and sedation. fluoxetine and tapentadol both increase serotonin levels. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Monitor Closely (1)sumatriptan intranasal and fluoxetine both increase serotonin levels. Your doctor may increase your dose as needed. Minor/Significance Unknown. Monitor Closely (2)fluoxetine and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)venlafaxine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. All material on this website is protected by copyright, Copyright 1994-2022 by WebMD LLC. Minor/Significance Unknown. Minor/Significance Unknown. Possible additive hyponatremia. Risk of weakness, dyspnea, chest pain. diflunisal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)maprotiline and fluoxetine both increase QTc interval. Monitor Closely (1)fluoxetine, aspirin/citric acid/sodium bicarbonate. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system, Serious - Use Alternative (1)fluoxetine will increase the level or effect of pirfenidone by affecting hepatic enzyme CYP1A2 metabolism. Serious - Use Alternative (1)fluoxetine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Risk of weakness, dyspnea, chest pain. thioridazine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. fluoxetine will increase the level or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Eating Plant-Based Omega-3s May Support Heart Health, Flax and flaxseed oil: an ancient medicine & modern functional food, Effect of flaxseed intervention on inflammatory marker C-reactive protein: A systematic review and meta-analysis of randomized controlled trials, The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients, Effects of linseeds on the symptoms of irritable bowel syndrome: a pilot randomised controlled trial, Flax fiber hydrophobic extract inhibits human skin cells inflammation and causes remodeling of extracellular matrix and wound closure activation, Flaxseed dietary fiber supplements for suppression of appetite and food intake, The effects of flaxseed on menopausal symptoms and quality of life. Avoid; coadministration of pirfenidone and moderate CYP1A2 inhibitors result in moderately increased exposure to pirfenidone; if unable to avoid, decrease dose of moderate CYP1A2 inhibitor. Avoid or Use Alternate Drug. The FDA approved Voltaren gel for OTC use based on the results of studies on its effectiveness and safety. Use Caution/Monitor. Minor (1)fenoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)triclabendazole and fluoxetine both increase QTc interval. Monitor Closely (1)zolmitriptan and fluoxetine both increase serotonin levels. cimetidine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)fluoxetine will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. If you log out, you will be required to enter your username and password the next time you visit. Modify Therapy/Monitor Closely.fenfluramine, fluoxetine. Modify Therapy/Monitor Closely. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)fluoxetine and lsd both increase serotonin levels. Monitor Closely (1)fluoxetine increases effects of edoxaban by anticoagulation. Minor/Significance Unknown. Serious - Use Alternative (1)fluoxetine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fluoxetine increases effects of insulin lispro by unspecified interaction mechanism. Contraindicated. Minor (1)acyclovir and methoxyflurane both increase nephrotoxicity and/or ototoxicity. fluoxetine and indapamide both increase QTc interval. When suggestions are available use up and down arrows to review and ENTER to select. Also called diclofenac 1%, Voltaren gel is approved by the U.S. Food and Drug Administration (FDA) to ease OA-related joint pain in the: This article will go over how Voltaren gel is used. fluoxetine will increase the level or effect of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Relief of all grades of pain and inflammation in a wide range of conditions, including: (i) arthritic conditions: rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout. Modify Therapy/Monitor Closely. Phenytoin: When using phenytoin concomitantly with diclofenac, monitoring of phenytoin plasma concentrations is recommended due to an expected increase in exposure to phenytoin. One analysis of multiple human studies found flaxseed contained compounds helpful for reducing C-reactive protein (an inflammation marker) in some of the study participants. Monitor Closely (1)clonidine, fluoxetine. Minor (1)fluoxetine will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. serotonin uptake by platelets. Concomitant use of PENNSAID and cyclosporine may increase cyclosporine's nephrotoxicity. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. serotonin uptake by platelets. SSRIs inhib. All material on this website is protected by copyright, Copyright 1994-2022 by WebMD LLC. Confusion, hallucinations, disturbances of sensation, malaise. Minor/Significance Unknown. Monitor Closely (1)fluoxetine and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)fluoxetine and trazodone both increase serotonin levels. About half of the administered diclofenac is metabolised during its first passage through the liver ("first-pass" effect), the area under the concentrations curve (AUC) following oral administration is about half that following an equivalent parenteral dose. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (1)fluoxetine, aspirin. Avoid or Use Alternate Drug. Minor/Significance Unknown. Macimorelin causes an increase of ~11 msec in the corrected QT interval. It contains many active compounds that are thought to provide benefits, including: Here are some of the potential health benefits of flaxseed oil and evidence to back up these claims. fluoxetine will increase the level or effect of diazepam intranasal by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Both drugs decrease blood glucose. Use Caution/Monitor. Use Caution/Monitor. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. netupitant/palonosetron, fluoxetine. Minor/Significance Unknown. Minor (1)acyclovir and vancomycin both increase nephrotoxicity and/or ototoxicity. Avoid; coadministration of pirfenidone and moderate CYP1A2 inhibitors result in moderately increased exposure to pirfenidone; if unable to avoid, decrease dose of moderate CYP1A2 inhibitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Monitor Closely (1)fluoxetine increases effects of tolazamide by unspecified interaction mechanism. Use Caution/Monitor.Serious - Use Alternative (1)fluoxetine and lorcaserin both increase serotonin levels. fluoxetine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Monitor Closely (1)fluoxetine and 5-HTP both increase serotonin levels. acyclovir and teicoplanin both increase nephrotoxicity and/or ototoxicity. serotonin uptake by platelets. UW Medicine Anesthesiology and Pain Medicine. fluoxetine will increase the level or effect of dexfenfluramine by affecting hepatic enzyme CYP2D6 metabolism. serdexmethylphenidate/dexmethylphenidate increases effects of fluoxetine by decreasing metabolism. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. SSRIs inhib. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and doxepin both increase serotonin levels. Use Caution/Monitor. Risk of long QT syndrome. Modify Therapy/Monitor Closely. When you use your PENNSAID pump bottle, you can hold the bottle at an angle. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Maxzide (Triamterene and Hydrochlorothiazide) Oral, Vimovo (Naproxen and Esomeprazole) - Oral, What to Know About Voltaren (Diclofenac Sodium). fluoxetine, safinamide. Flaxseed oil is available as an oil used in food preparation and in gelcap supplements. Coadministration of gilteritinib with drugs that inhibit 5HT2B or sigma nonspecific receptors. Use Caution/Monitor. fluoxetine increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of weakness, dyspnea, chest pain. Use Caution/Monitor. Lana Barhum has been a freelance medical writer for over 10 years. Modify Therapy/Monitor Closely. For patients currently taking pitolisant, reduce pitolisant dose by half upon initiating strong CYP2D6 inhibitors.Serious - Use Alternative (1)fluoxetine and pitolisant both increase QTc interval. Comment: Defibrotide may enhance effects of platelet inhibitors. For example, don't just use Voltaren on your own without asking your provider first if you have: Voltaren will come with a dosing card that you can use to measure the correct dose of the gel. Serious - Use Alternative (1)palonosetron, fluoxetine. Avoid coadministration of abiraterone with substrates of CYP2D6. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of fluoxetine by decreasing metabolism. Modify Therapy/Monitor Closely. Strong or moderate CYP2C19 inhibitors may decrease rate of diazepam elimination, thereby increasing adverse reactions to diazepam. Use Caution/Monitor. There is no typical clinical picture resulting from diclofenac over dosage. Use Caution/Monitor. acyclovir will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. This drug is available at a middle level co-pay. Monitor Closely (1)fluoxetine, nabumetone. Typical manufacturer recommendations range from 720 mg to 1650 mg daily, but you should always talk to your healthcare provider before you add any new supplement to your diet. ethacrynic acid, fluoxetine. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. fluoxetine and glasdegib both increase QTc interval. Contraindicated.thioridazine and fluoxetine both increase QTc interval. SSRIs inhib. Avoid or Use Alternate Drug.propafenone will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. QTc interval. Compare formulary status to other drugs in the same class. However, a small study of a topical flaxseed oil gel found it safe and effective for carpal tunnel syndrome. fluoxetine and lsd both increase serotonin levels. Both drugs decrease blood glucose.fluoxetine increases effects of insulin inhaled by unspecified interaction mechanism. acyclovir will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. acyclovir and methoxyflurane both increase nephrotoxicity and/or ototoxicity. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvem92aXJheC1hY3ljbG92aXItMzQyNjAx, View explanations for tiers and fluoxetine will increase the level or effect of mexiletine by affecting hepatic enzyme CYP2D6 metabolism. amitriptyline and fluoxetine both increase QTc interval. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.perphenazine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)defibrotide increases effects of fluoxetine by Other (see comment). Long-term use of Voltaren gel may increase your risk of heart attack or stroke. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation. Use Caution/Monitor. Monitor Closely (1)lurasidone, fluoxetine. Contraindicated. Modify Therapy/Monitor Closely. Generic drugs usually cost less than brand-name versions. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Risk of neurotoxicity. They're all similarly effective, although you may find a particular one works best for you. Either increases effects of the other by serotonin levels. Monitor Closely (1)selpercatinib increases toxicity of fluoxetine by QTc interval. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Increased risk of upper GI bleeding. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Monitor Closely (1)ciprofloxacin and fluoxetine both increase QTc interval. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. fluoxetine increases effects of insulin glargine by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Use Caution/Monitor. No adverse effects were observed using indirect ophthalmoscopy after multiple-daily dermal application to rats for 26 weeks and minipigs for 52 weeks of DMSO at twice the concentration found in PENNSAID. bendroflumethiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. View the formulary and any restrictions for each plan. Minor/Significance Unknown. Monitor Closely (1)amiodarone will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. fluoxetine and levoketoconazole both increase QTc interval. Risk of weakness, dyspnea, chest pain. fluoxetine and ergotamine both increase serotonin levels. fentanyl transmucosal, fluoxetine. Symptoms may include fever, chills, body aches, mouth sores, and severe diarrhea. Fresh flaxseed oil has a mild, nutty aroma reminiscent of sunflower or sesame seeds and tastes crisp and mildly nutty. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. fluoxetine and venlafaxine both increase QTc interval. Increased risk of upper GI bleeding. Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs. Contraindicated. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Monitor Closely (3)fluoxetine will increase the level or effect of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. SSRIs inhib. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. fluoxetine and milnacipran both increase serotonin levels. Coadministration may increase risk of serotonin syndrome. oxaprozin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system. Use Caution/Monitor. serotonin uptake by platelets. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.fluoxetine, diclofenac. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of fluoxetine by unknown mechanism. Monitor Closely (1)fluoxetine and quinine both increase QTc interval. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation. This may occur in patients with or without a previous history of epilepsy or convulsions. These are not all the possible side effects of NSAIDs. lornoxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Serious - Use Alternative (3)perphenazine and fluoxetine both increase QTc interval. Use Caution/Monitor.Minor (1)fluoxetine, lithium. darifenacin will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Ask your pharmacist about using those products safely.This medication may interfere with certain medical/laboratory tests (including brain scan for Parkinson's disease), possibly causing false test results. Acylglucuronidation mediated by UGT2B7 and oxidation mediated by CYP2C8 may also play a role in diclofenac metabolism. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Mixing skin products can also change how your body absorbs and reacts to the NSAID gel. Monitor Closely (1)fluoxetine, choline magnesium trisalicylate. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Concomitant use of diclofenac with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [see. Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. fluoxetine increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. Discontinue buprenorphine if serotonin syndrome is suspected. The drug works by blocking a particular enzyme in your body. Modify Therapy/Monitor Closely. These joints include those in your hands and knees. Minor (1)willow bark will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Avoid or Use Alternate Drug. This medication may also help reduce how long pain remains after the sores heal. Other (see comment). willow bark will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. sufentanil SL, fluoxetine. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)fluoxetine will increase the level or effect of pitolisant by affecting hepatic enzyme CYP2D6 metabolism. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Voltaren will come with a dosing card that you can use to measure the correct dose of the gel. Always carry the original prescription-labeled container with you. fluconazole and fluoxetine both increase QTc interval. Do not crush or chew the contents of the capsule. SSRIs inhib. fenoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. If you are using a PENNSAID pump bottle follow the steps below: Before you use PENNSAID pump bottle for the first time, you will need to prime the pump. For people with kidney disease or taking diuretics: If you have kidney disease or take diuretics (water pills), theres a risk this drug can affect your kidneys ability to remove excess water from your body. Serious - Use Alternative (1)siponimod and fluoxetine both increase QTc interval. acyclovir and pentamidine both increase nephrotoxicity and/or ototoxicity. Consider the risk of untreated depression when discontinuing or changing treatment with antidepressant medication during pregnancy and postpartum. Minor/Significance Unknown. Help us improve emc by letting us know which of the following best describes you, 2. aspirin rectal will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Contraindicated. Avoid or Use Alternate Drug. fluoxetine and lithium both increase serotonin levels. The Top Products for Arthritis Pain in Hands, Don't Take Aspirin and Warfarin Together, Researchers Say: Here's Why. Avoid or Use Alternate Drug.propafenone and fluoxetine both increase QTc interval. Monitor Closely (1)fluoxetine and isoniazid both increase serotonin levels. Avoid or Use Alternate Drug. peginterferon alfa 2b, fluoxetine. Use Caution/Monitor. Caution when peramivir coadministered with nephrotoxic drugs. Minor/Significance Unknown. David Ozeri, MD, is a board-certified rheumatologist from Tel Aviv, Israel specializing in arthritis, autoimmune diseases, and biologic therapies. Examples of other NSAIDs include: Taking diclofenac with other drugs that affect the flow of blood through your body can increase your risk of bleeding. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)frovatriptan and fluoxetine both increase serotonin levels. Serious - Use Alternative (1)fluoxetine and ibutilide both increase QTc interval. Use Caution/Monitor. fluoxetine and levalbuterol both increase QTc interval. osimertinib and fluoxetine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. fluoxetine will increase the level or effect of haloperidol by affecting hepatic enzyme CYP2D6 metabolism. What Is the Difference Between Mobic (Meloxicam) and Ibuprofen? Monitor Closely (1)fluoxetine, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Assess need to reduce dose of CYP2D6-metabolized drug. fluoxetine, choline magnesium trisalicylate. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. This website also contains material copyrighted by 3rd parties. Minor/Significance Unknown. Use Caution/Monitor. SSRIs affect platelet activation; coadministration of SSRIs with clopidogrel may increase the risk of bleeding.Serious - Use Alternative (1)fluoxetine decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely.Minor (1)nilotinib will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Inhibition of CYP2D6 metabolism to tamoxifen's active metabolite, endoxifen. Thank you, {{form.email}}, for signing up. Coadministration may potentiate the CNS-depressant effects of each drug. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. thiothixene and fluoxetine both increase QTc interval. Adults can take a dose of OTC ibuprofen every 4 to 6 hours. Use Caution/Monitor. Do not give NSAIDs to other people, even if they have the same symptoms that you have. Monitor your blood sugar regularly and share the results with your doctor. fluoxetine will increase the level or effect of oliceridine by affecting hepatic enzyme CYP2D6 metabolism. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Monitor Closely (2)fluoxetine will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration enhances CNS depressant effects. Avoid combination within 14 days of MAOI use. Minor/Significance Unknown. NOTE: In MDD clinical trials, brexpiprazole dosage was not adjusted for strong CYP2D6 inhibitors (eg, paroxetine, fluoxetine); thus, CYP considerations are already factored into general dosing recommendations and brexpiprazole may be administered without dosage adjustment in patients with MDD. Serious - Use Alternative (1)fluoxetine and pentamidine both increase QTc interval. Diclofenac gel can transfer to others. Mechanism: unknown. Consider reducing valbenazine dose based on tolerability if coadministered with a strong CYP2D6 inhibitor. Contraindicated. Modify Therapy/Monitor Closely. dichlorphenamide and fluoxetine both decrease serum potassium. Monitor Closely (1)fluoxetine and ziprasidone both increase QTc interval. 2017;22(3):462-467. doi:10.1177/2156587216677822. fluoxetine will increase the level or effect of iloperidone by affecting hepatic enzyme CYP2D6 metabolism. SSRIs inhib. SSRIs inhib. Modify Therapy/Monitor Closely. This interaction is mediated through accumulation of methotrexate resulting from impairment of renal excretion in the presence of the NSAID. Images. fluoxetine will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tetrabenazine and fluoxetine both increase QTc interval. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system. fluoxetine and daridorexant both increase sedation. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Monitor Closely (2)acyclovir and tenofovir DF both increase nephrotoxicity and/or ototoxicity. acyclovir increases levels of emtricitabine by Other (see comment). Use Caution/Monitor. Monitor Closely (1)fluoxetine and vilanterol/fluticasone furoate inhaled both increase QTc interval. serotonin uptake by platelets. fluoxetine will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Either increases effects of the other by anticoagulation. fluoxetine and posaconazole both increase QTc interval. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Limit alcoholic beverages. MISSED DOSE: If you miss a dose, take it as soon as you remember. Avoid or Use Alternate Drug. Minor/Significance Unknown. Serious - Use Alternative (1)desflurane and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely. Use Caution/Monitor. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Do not double the dose to catch up. Avoid or Use Alternate Drug. Risk of QT interval prolongation. serotonin uptake by platelets. mefloquine increases toxicity of fluoxetine by QTc interval. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2C9 substrates. Use Caution/Monitor. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. fluoxetine and dihydroergotamine intranasal both increase serotonin levels. Theoretical interaction. Increases risk of torsades de pointes. fluoxetine, insulin inhaled. Avoid or Use Alternate Drug. Use Caution/Monitor. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)fluoxetine and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.Minor (1)fluoxetine, frovatriptan. Minor/Significance Unknown. Monitor Closely (1)epinephrine racemic and fluoxetine both increase QTc interval. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. In addition, increased incidences of various malformations, including cardiovascular, have been reported in animals given a prostaglandin synthesis inhibitor during the organogenetic period. Modify Therapy/Monitor Closely. fluoxetine increases effects of insulin aspart protamine/insulin aspart by unspecified interaction mechanism. NOTE: In MDD clinical trials, brexpiprazole dosage was not adjusted for strong CYP2D6 inhibitors (eg, paroxetine, fluoxetine); thus, CYP considerations are already factored into general dosing recommendations and brexpiprazole may be administered without dosage adjustment in patients with MDD. Minor/Significance Unknown. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Monitor Closely (1)arformoterol and fluoxetine both increase QTc interval. Minor (1)balsalazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Diclofenac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Monitor Closely (1)acyclovir will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. use sunlamp and tanning beds. Minor/Significance Unknown. buprenorphine, long-acting injection and fluoxetine both increase QTc interval. Use Caution/Monitor. Talk with your healthcare provider or pharmacist if you are not sure. clarithromycin and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Rheumatol Ther. The absolute risk for cardiovascular malformation was increased from less than 1%, up to approximately 1.5 %. Monitor Closely (1)olanzapine and fluoxetine both increase QTc interval. Below is a list of medications that can interact with Diclofenac. Use Caution/Monitor. acyclovir and tacrolimus both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Use Caution/Monitor. Other (see comment). Find out if kids need different sunscreens from adults, if sunscreen can be toxic, and whether it matters if youre slathering on SPF 100. Coadministration enhances CNS depressant effects. Avoid or Use Alternate Drug.quinidine and fluoxetine both increase QTc interval. Minor/Significance Unknown. Increased risk of upper GI bleeding. Avoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleeding. When filling your prescription, be sure to call the pharmacy first to make sure they stock this drug or can order it for you. Mechanism: unknown. Therefore, the combination should be administered with caution and patients, especially the elderly, should have their blood pressure periodically monitored. fluoxetine will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Use Caution/Monitor. Modify Therapy/Monitor Closely. fluoxetine will increase the level or effect of nifedipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Voltaren can also cause you to have higher levels of a type of white blood cell (WBC) called eosinophils. Serious - Use Alternative (1)buprenorphine and fluoxetine both increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. Use Caution/Monitor. Consider reducing the dose when concomitantly using CYP2C9 substrates. Use Caution/Monitor. serotonin uptake by platelets. The concomitant use of diclofenac with other NSAIDs or salicylates is not recommended. fluoxetine, sumatriptan intranasal. Avoid or Use Alternate Drug. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Minor (1)cefamandole will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine, long-acting injection and fluoxetine both increase QTc interval. fluoxetine, buprenorphine, long-acting injection. Dont use this drug again if youve ever had an allergic reaction to it. Serious - Use Alternative (1)vemurafenib and fluoxetine both increase QTc interval. Closely monitor for evidence of seizures when using bowel preps together with drugs that lower the seizure threshold. SSRIs inhib. Use Caution/Monitor. Use Caution/Monitor. This list does not contain all drugs that may interact with Diclofenac. Avoid or Use Alternate Drug. prescription products. Use Caution/Monitor. Diclofenac topical gel may cause drowsiness. Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.Rarely, males may have a painful or prolonged erection lasting 4 or more hours. Minor/Significance Unknown. A prescription for this medication is refillable. Modify Therapy/Monitor Closely. The benefits of using diclofenac during pregnancy may outweigh the potential risks in certain cases. This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)escitalopram and fluoxetine both increase serotonin levels. primaquine and fluoxetine both increase QTc interval. SSRIs inhib. ezogabine and fluoxetine both increase QTc interval. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. fluoxetine, meclofenamate. Either increases toxicity of the other by pharmacodynamic synergism. Using diclofenac with certain blood pressure medications may also increase your risk of kidney damage. Either increases toxicity of the other by serotonin levels. Monitor Closely (2)fluoxetine increases effects of insulin degludec by unspecified interaction mechanism. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)acyclovir and ioversol both increase nephrotoxicity and/or ototoxicity. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. fluoxetine, etodolac. Monitor Closely (1)vorinostat and fluoxetine both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. On a blood test, your levels might be higher than normal even before you have symptoms. Avoid or Use Alternate Drug. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Avoid or Use Alternate Drug. evere CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. The medication also contains ammonia, carbomer homopolymer type C, coco-caprylate/caprate, isopropyl alcohol, mineral oil, polyoxyl 20 cetostearyl ether, proplyene glycol, and water. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Additive antiplatelet effect may occur; SSRIs and SNRIs may cause platelet serotonin depletion . Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. The total dosage of diclofenac gel shouldnt be more than 32 gm per day, over all affected joints. The apparent half-life for elimination from the synovial fluid is 3-6 hours. Modify Therapy/Monitor Closely. During prolonged treatment with diclofenac, as with other NSAIDs, monitoring of the blood count is recommended. Avoid or Use Alternate Drug. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Increased risk of upper GI bleeding. SIDE EFFECTS: See also Warning section.Nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning may occur. Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)fluoxetine will increase the level or effect of methamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Drink plenty of fluids while taking this medication unless your doctor directs you otherwise.If you are using the liquid form of this medication, shake the bottle well before each dose. Avoid or Use Alternate Drug. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). fluoxetine, ibuprofen IV. fluoxetine and morphine both increase serotonin levels. Minor/Significance Unknown. Serotonin release by platelets plays an important role in hemostasis. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Use Caution/Monitor. Monitor Closely (1)efavirenz and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (2)acyclovir, elvitegravir/cobicistat/emtricitabine/tenofovir DF. Monitor Closely (1)nitisinone will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Minor (1)astragalus increases effects of acyclovir by pharmacodynamic synergism. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.Serious - Use Alternative (1)eliglustat and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system. Avoid or Use Alternate Drug. Either increases effects of the other by serotonin levels. It's a generic prescription drug used to treat severe pain in certain, Researchers say aspirin and warfarin are different types of blood thinners, but they can increase the risk of excessive bleeding if taken together, Prescription naproxen oral tablet helps reduce swelling and pain. Either increases toxicity of the other by serotonin levels. Contraindicated. fluoxetine and ziprasidone both increase QTc interval. serotonin uptake by platelets. Avoid or Use Alternate Drug. fluoxetine, acemetacin. Monitor Closely (1)apalutamide will decrease the level or effect of fluoxetine by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Diclofenac may decrease the blood pressure-lowering effects of some drugs used to control blood pressure. fluoxetine and pentazocine both increase serotonin levels. Share cases and questions with Physicians on Medscape consult. Use Caution/Monitor. Either increases effects of the other by serotonin levels. Avoid taking selinexor with other medications that may cause dizziness or confusion. Use Caution/Monitor. fluoxetine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Accumulation does not occur, provided the recommended dosage intervals are observed. However, taken in larger quantities, flaxseed oil can have a laxative effect. People with OA usually have joint pain, swelling, and stiffness. Either increases toxicity of the other by pharmacodynamic synergism. Concurrent use of metoclopramide intranasal and strong CYP2D6 inhibitors is not recommended since the metoclopramide intranasal dose cannot be adjusted. Monitor Closely (2)fluoxetine will increase the level or effect of oliceridine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Avoid drinking alcohol when using this drug. Monitor patients for symptoms of serotonin syndrome if SSRIs are coadministered with safinamide. ECG monitoring is recommended, along with drugs that may prolong the QT interval. If you miss doses or dont take the drug on schedule: Your medication may not work as well or may stop working completely. Consider initiating nifedipine at the lowest dose available if given concomitantly with this medication. SSRIs inhib. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Monitor Closely (2)fluoxetine will increase the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Either increases toxicity of the other by serotonin levels. vorinostat and fluoxetine both increase QTc interval. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Use Caution/Monitor. Monitor for signs of opioid withdrawal. This list is not complete. fluoxetine, fenbufen. Either increases toxicity of the other by QTc interval. Increased risk of upper GI bleeding. Minor/Significance Unknown. serotonin uptake by platelets. SSRIs inhib. fluoxetine, sumatriptan. Avoid or Use Alternate Drug. Use Caution/Monitor. Diclofenac topical gel is available as the brand-name drugs Solaraze and Voltaren. 2016;151(3):275-280. Use Caution/Monitor. fluoxetine, vandetanib. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Contraindicated. fluoxetine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Contraindicated. indomethacin will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Either increases effects of the other by sedation. Use Caution/Monitor. Use Caution/Monitor. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Diclofenac sodium in vitro does not suppress proteoglycan biosynthesis in cartilage at concentrations equivalent to the concentrations reached in human beings. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. Monitor Closely (1)fluoxetine, safinamide. Increased risk of upper GI bleeding. Minor/Significance Unknown. Monitor Closely (1)temocillin, acyclovir. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgSerious - Use Alternative (1)fluoxetine and desvenlafaxine both increase serotonin levels. Use Caution/Monitor. fluoxetine will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Initiate with lower doses and monitor patients for signs and symptoms of serotonin syndrome, particularly during dextroamphetamine initiation and after a dosage increase. Risk of QT interval prolongation. Minor/Significance Unknown. Contraindicated. Minor (1)lornoxicam will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.fluoxetine and voriconazole both increase QTc interval. fluoxetine, lithium. encorafenib and fluoxetine both increase QTc interval. Do not exceed 18 mg/dose and 36 mg/day of deutetrabenazine if coadministered with strong CYP2D6 inhibitors.deutetrabenazine and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and sertraline both increase serotonin levels. Use Caution/Monitor. Monitor Closely (1)lamotrigine increases toxicity of fluoxetine by unspecified interaction mechanism. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (1)fluoxetine will increase the level or effect of mexiletine by affecting hepatic enzyme CYP2D6 metabolism. The recommended maximum daily dose of diclofenac sodium is 150mg. Always ask your health care professional for complete information about this product and your specific health needs. almotriptan and fluoxetine both increase serotonin levels. Monitor Closely (2)prochlorperazine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)fluoxetine will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. It may harm them. Contraindicated (1)artemether/lumefantrine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. As with other NSAIDs, the use of diclofenac may impair female fertility and is not recommended in women attempting to conceive. Other drugs may interact with losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Either increases levels of the other by decreasing renal clearance. fluoxetine, nabumetone. fluoxetine and methadone both increase QTc interval. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. Contraindicated. Monitor Closely (1)dofetilide and fluoxetine both increase QTc interval. lumefantrine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. It comes in immediate-release and extended-release forms. Monitor Closely (1)darunavir will increase the level or effect of fluoxetine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Possible additive hyponatremia. Modify Therapy/Monitor Closely. Use Caution/Monitor.fluoxetine, ibuprofen. Modify Therapy/Monitor Closely. A: Generally acceptable. Methylene blue may increase serotonin as a result of MAO-A inhibition. Monitor Closely (1)mipomersen, fluoxetine. Minor (1)celandine decreases effects of fluoxetine by pharmacodynamic antagonism. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Serious - Use Alternative (1)selinexor, fluoxetine. Use Caution/Monitor. Canada residents can call a provincial poison control center. Avoid or Use Alternate Drug. acyclovir and cidofovir both increase nephrotoxicity and/or ototoxicity. Anyone who is concerned about the effects of flaxseed oil on their prostate should check with their healthcare provider before adding flaxseed oil to their diet. A: Generally acceptable. Avoid or Use Alternate Drug. Monitor Closely (1)erythromycin stearate and fluoxetine both increase QTc interval. tranylcypromine and fluoxetine both increase serotonin levels. Either increases toxicity of the other by pharmacodynamic synergism. To lower the chance of giving herpes to your partner, do not have sexual contact during an outbreak or if you have symptoms. Minor/Significance Unknown. Use Caution/Monitor. 7, Sopwith Way, Drayton Fields, Daventry, Northamptonshire, NN11 8PB, UK. Use Caution/Monitor. Avoid or Use Alternate Drug. fluoxetine and dextroamphetamine both increase serotonin levels. Use Caution/Monitor. Minor (1)fluoxetine will increase the level or effect of rabeprazole by affecting hepatic enzyme CYP2C19 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Do not have certain immunizations/vaccinations (such as vaccines against the varicella virus) without the consent of your doctor.Older adults may be more sensitive to the side effects of the drug, especially kidney problems (change in the amount of urine, back/side pain), dizziness, drowsiness, and mental/mood changes (such as confusion, hallucinations, loss of consciousness).Acyclovir does not protect against the spread of genital herpes. Anticoagulants and anti-platelet agents: Caution is recommended since concomitant administration could increase the risk of bleeding (see section 4.4). Use Caution/Monitor. Minor/Significance Unknown. Minor (1)aspirin/citric acid/sodium bicarbonate will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. You should always talk to your provider before you start or stop any OA treatment. Avoid or Use Alternate Drug. You may report side effects to Health Canada at 1-866-234-2345. Monitor Closely (1)cobicistat will increase the level or effect of fluoxetine by Other (see comment). Monitor for drug toxiticities when initiating or discontinuing methylphenidate. PRECAUTIONS: Before taking acyclovir, tell your doctor or pharmacist if you are allergic to it; or to valacyclovir; or if you have any other allergies. If also administered with a strong/moderate CYP3A4 inhibitor, administer a quarter of brexpiprazole dose. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice.AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more maprotiline and fluoxetine both increase QTc interval. serotonin uptake by platelets. Oral versus topical diclofenac sodium in the treatment of osteoarthritis. tedizolid, fluoxetine. Combinations is contraindicated within 5 weeks of MAOI use. Copyright(c) 2022 First Databank, Inc. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using fluoxetine and each time you get a refill. Monitor Closely (1)fluoxetine will increase the level or effect of alosetron by affecting hepatic enzyme CYP2C9/10 metabolism. fluoxetine, aceclofenac. Contraindicated. Fish Oil for Arthritis and Joint Pain: Can It Help? Avoid or Use Alternate Drug.Minor (1)duloxetine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Decrease tetrabenazine dose by 50% when coadministered with strong CYP2D6 inhibitors. Taking methotrexate with diclofenac can lead to harmful levels of methotrexate in your body. Avoid or Use Alternate Drug.fluoxetine and sertraline both increase serotonin levels. efavirenz and fluoxetine both increase QTc interval. Panobinostat is known to significantly prolong QT interval. Use Caution/Monitor. bupropion will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of fluoxetine by affecting hepatic enzyme CYP2C9/10 metabolism. acyclovir and adefovir both increase nephrotoxicity and/or ototoxicity. fluoxetine will increase the level or effect of propranolol by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by serotonin levels. fluoxetine increases toxicity of methylenedioxymethamphetamine by decreasing elimination. Biomed Res Int. Before you use Voltaren in any form, you should tell your provider about any other medications or supplements you take. Modify Therapy/Monitor Closely. Consider reducing the cannabidiol dose when coadministered with a moderate CYP2C19 inhibitor.cannabidiol will increase the level or effect of fluoxetine by decreasing metabolism. celecoxib will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Serious - Use Alternative (1)fluoxetine and indapamide both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)abiraterone increases levels of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (2)fluoxetine and lithium both increase serotonin levels. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding. Usually, 0.5 grams (gm) of gel is used for each site thats 2 inches by 2 inches (5 centimeters by 5 centimeters). As a precautionary measure due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2D6 inhibitors. If gastrointestinal bleeding or ulceration occurs in patients receiving diclofenac, the medicinal product should be withdrawn. Contraindicated (1)selegiline and fluoxetine both increase serotonin levels. Tieppo Francio V, Davani S, Towery C, Brown TL. 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